Mircette (Desogestrel and Ethinyl Estradiol)

Mircette is biphasic combined oral contraceptive containing 2 hormones: desogestrel and ethinyl estradiol. It is prescribed as the means for pregnancy prevention and planning.

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Table of Contents




This birth control provides fast and complete absorption. Its bioavailability is 70%. It is almost completely bound to plasma proteins. It is rapidly metabolized in the intestinal wall and in the liver to form an active metabolite (etonogestrel). The effective half-life is 30 hours. It is excreted by the kidneys and through the gastrointestinal tract.

Ethinyl Estradiol

Mircette is quickly and completely absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is reached within 1-2 hours after application. Its bioavailability is 60%. It is assimilated with blood plasma proteins by 97.5%. Metabolized in the liver and intestines to etonogestrel. The effective half-life is 24 hours. 45% is excreted by the kidneys and 30% by the gastrointestinal tract. The effective half-life is approximately 24 hours.

How does it work?

This birth control contraceptive contributes to a decrease in serum concentrations of follicle-stimulating and luteinizing hormone. It also suppresses ovulation, increases the viscosity of the cervical secretions. It is well-known by the difficulty of sperm penetration through the fallopian tube. Mircette causes endometrium rearrangement, which makes it difficult to implant the fertilized egg.

In addition to contraceptive properties, this combined oral contraceptive has a number of effects that can be taken into account when selecting a contraceptive method. Menstruation becomes more regular, less painful and less abundant. These circumstances lead to a decrease in the frequency of concomitant iron deficiency anemia.

Indications for use

It is used as an oral contraceptive drug for systemic use, to prevent unwanted pregnancy. The drug reduces the intensity of bleeding during menstruation, reduces the likelihood of ovarian cysts, reduces the risk of developing endometrial and ovaries cancer.Mircette_ Effective Birth Control Means


It is prescribed for daily application – 1 tablet at the same time for 28 days without interruptions. The first tablet from the first package is taken on the first day of the menstrual cycle. Reception from the subsequent packing begins after all the pills are taken from the first blister.

  • After childbirth; from the first day of menstruation;
  • After abortion and miscarriage – immediately.

Every woman should strictly adhere to the recommendations of the doctor and instructions for use.

Side effects

  • Headache, migraine;
  • Frequent mood changes;
  • The appearance of unpleasant sensations in the cornea when wearing contact lenses;
  • Thrombosis;
  • High blood pressure;
  • Nausea, vomiting;
  • Cholelithiasis, cholestatic jaundice;
  • Tenderness of the mammary glands (breast milk may appear);
  • Intermenstrual bleeding;
  • Amenorrhea (after discontinuation);
  • Changes in cervical secretion;
  • An increase in the size of the uterine fibroids;
  • Aggravation of endometriosis;
  • Vaginal microbial diseases (including candidiasis);
  • Fluid retention;
  • Change in body weight;
  • Chloasma;
  • Nodular erythema;
  • Rash;
  • Decreased glucose sensitivity.


Missed pills

Full contraceptive effect is maintained under the condition of systematic administration of pills (maximum delay – no more than 12 hours). If more time has passed, then the next day, a woman should take 2 tablets at the usual time using additional contraceptives for the next 14 days or until the next menstruation.

Drug interactions

Preparations inducing liver enzymes, such as hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, and St. John’s wort-containing drugs reduce the effectiveness of oral contraceptives provoking the risk of bleeding. They increase the risk of intermenstrual bleeding. The maximum level of induction is usually achieved not earlier than 2-3 weeks but can last up to 4 weeks after drug discontinuation.

Ampicillin, tetracycline – reduce effectiveness (interaction mechanism is not confirmed).

It is recommended to use an additional barrier method of contraception during the entire course of treatment and for 7 days (for rifampicin – within 28 days) after drug discontinuation.


Katie Lees: “I take Mercette 28. Everything is ok. No weight gain, no hair loss, no health harms. But it is necessary to visit the gynecologist for doing the tests for hormones and pick the birth control up.”

Keira Baker: “Those who say that they didn’t pick up suitable birth control, in most cases, choose them themselves and then complain about what horrible pills they are. Doctors have repeatedly told women only they should decide what kind of contraceptive means to take. I have been taking Mircette for almost 8 years with breaks, including during pregnancy. I am satisfied, children were born in the family at the appropriate time and I did not have to make abortion as many people do. Mircette never failed me, my weight is normal, I even lost a little after I started taking it. The main thing is not to prescribe it to yourself, consult your doctor. All drugs have contraindications and side effects, remember this.”