Yasmin (Drospirenone and Ethinyl Estradiol)

Yasmin (drospirenone/ethinyl estradiol) is a combined oral contraceptive produced to suppress ovulation and prevent pregnancy. The course lasts for 28 days with 7 placebo pills to maintain a required hormone level.

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Table of Contents




When taken orally, drospirenone is rapidly and almost completely absorbed. After a single oral dose, serum Cmax of drospirenone, equal to 37 ng/ml, is achieved within 1–2 hours. Its bioavailability ranges from 76 to 85%. A diet regimen does not affect the bioavailability of drospirenone.

During the cycle treatment, the maximum equilibrium concentration of drospirenone in serum is reached in the second half of the cycle. A further increase in the serum concentration of this substance is noted after 1-6 courses of administration, after which there is no increase in concentration.

Ethinyl Estradiol

After oral administration, ethinyl estradiol is rapidly and completely absorbed. Plasma Cmax, equal to about 54–100 pg/ml, is achieved within 1–2 hours. During absorption and first processing through the liver, ethinyl estradiol is metabolized. As a result, its bioavailability is approximately 45% when taken orally.

Ethinyl estradiol is almost completely (approximately 98%) bound by albumin. Ethinyl estradiol induces the synthesis of SHBG.

Ethinyl estradiol undergoes pre-systemic conjugation, both in the small intestinal mucosa and in the liver. The main pathway of metabolism is aromatic hydroxylation.

How to use?

The drug is taken 1 tablet per day, at the same time of the day. When you decide to take birth control pills you should follow the indications specified on the blister. Tablets are taken for 28 days in a row. Each next package starts 7 placebo pills after the previous one has ended. Bleeding begins 2-3 days after the end of the package and does not have to end before the next package starts.

How long does it take to be effective?

In the absence of taking any hormonal contraceptives in the previous cycle, Yasmin is taken on the 1st day of the menstrual cycle (that is, on the 1st day of menstrual bleeding). It is allowed to start taking this birth control on the 2-5th day of the menstrual cycle, but in this case, it is recommended to additionally use a barrier method of contraception during the first 7 days of taking the tablets from the first package.
Yasmin_ Number 1 Birth Control Means


These tablets should be taken orally in the order indicated on the packaging, every day at about the same time, with a small amount of water. Take 1 tab./day continuously for 28 days. Taking the pills from the next pack begins after 7 inactive pills, during which menstruation bleeding usually starts (withdrawal bleeding).

Side effects

Yasmin is a well-tolerated drug but has a number of side effects. They are:

  • Mental disorders: often – mood swings, depression/depressed mood, decrease or loss of libido.
  • Nervous system: often – migraine.
  • Cardiovascular system: rarely – venous or arterial thromboembolism.
  • Digestive system: often – nausea.
  • Skin and subcutaneous tissues: the frequency is unknown – erythema multiforme.
  • Reproductive system and the mammary gland: often – pain in the mammary glands, irregular uterine bleeding, bleeding of unspecified genesis.


Missed pills

If the application is missed, then the next pill should be taken as soon as you remember it. The next pill is taken the next day at the usual time. However, if the missing period was less than 24 hours, then the contraceptive properties of the drug are not reduced. If the break lasts for more than 24 hours, then the contraceptive effect can be reduced.


The interaction of oral contraceptives with other drugs can result in breakthrough bleeding and/or a decrease in contraceptive reliability. Women taking these drugs should temporarily use barrier methods of contraception in addition to Yasmin or choose another method of contraception.

It is not recommended to combine this birth control with the following drug categories:

  • drugs that induce liver microsomal enzymes (phenytoin, barbiturates, primidone, carbamazepine, rifampicin, rifabutin, possibly oxcarbazepine, topiramate, felbamate, griseofulvin, and St. John’s wort preparations.);
  • HIV protease inhibitors (ritonavir);
  • some antibiotics (for example, penicillin and tetracycline).



Benefits of combined oral contraceptives including Yasmin:

  • fast action and high efficiency;
  • ease of use;
  • do not affect sensations during sexual intercourse;
  • the prevention of some infertility causes.



Brooke Burgess: “It is an effective drug. Well-tolerated. Most women from my surrounding note an improvement in their general condition. Unfortunately, there are swings in the nervous system. The drug is easy to use. With the discontinuation of the drug for the desired pregnancy, it gives a good performance. In the future, a woman can also return to it.”

Sofia Douglas: “The drug has proven itself in the pharmaceutical market for a long time as a quality contraceptive! Side effects are usually few, uterine bleeding was not observed and confirmed. After its withdrawal, the desired pregnancy occurs, which is a very great advantage.”

Amelie Foster: “I have only the best reviews about this drug. Took almost for 3 years – improved face skin, hair loss decreased, painless menstruation, there were no mood changes. I recommend it but after a doctor’s examination.”

Molly O’Brien: “One of the most effective means of unwanted pregnancy, will help regulate the menstrual cycle, may help to cope with hormonal changes (pimples and rashes). The last is a purely individual thing, it does not help everyone.”